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Последние исследования показывают, что более трех миллионов человек в Соединенных Штатах, имеют болезнь Альцгеймера (AD). Это число будет увеличиваться по мере старения населения, удвоевшись к 2040 году в Западной Европе и утроившись в Восточной Европы. Таким образом, поиск эффективных методов лечения и ранней диагностики имеет решающее значение.Особенностью (AD) является наличие β-амилоида (β-amiloide (Aβ)), это цитотоксических пептид, в виде внеклеточной совокупности (тромбоцитов) в головном мозге. STAB VIDA участвует v проектe, который планирует  использовать наночастицы (NPS) для диагностики и терапии, в одиночку или в соединении (teragnóstico), с особым акцентом на мозговой β-амилоида. Мозговой и кровяной  β-амилоиды находятся в равновесии вдоль гематоэнцефалического барьера (ВВВ), таким образом, что проект также считает β-амилоид крови в качестве потенциальной цели. Различные NPS (липосомы, твердых наночастиц липидов NPS, NPS полимерных), будут функциональными с:


I) молекулами, которые взаимодействуют с Aβ;
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Искусственные и клеточные модели будут использованы для совершенствования привязки NPS Aβ, тестирования биосовместимости, переход через BBB и физической стабильности, что позволяет минимизировать использование животных, хотя эффективность (NPS) будет в конечном счете утверждена с использыванием животных моделей. Будут использованы различные пути введения (например, оральный, носовые) или различных протоколы (двухступенчатый (two-step), коктейли (cocktails de NP), аэрозолей с целью увеличения поставок NPS в мозг. Ожидается, что NPS обладают способностью выявления, охватывания и разцепления, пресечения ВВВ и удалиния β-амилоида из головного мозга. Кроме того, они будут взаимодействовать с β-амилоидом крови, таким образом изымая из мозга избыточный пептид посредством эффекта поглощения. NPS, которые имеют возможность пересечь BBB, могут также иметь потенциал для применения в фармацевтической промышленности.

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