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Estudos recentes sugerem que mais de três milhões de pessoas nos Estados Unidos têm doença de Alzheimer (AD). Este número está destinado a aumentar com o envelhecimento da população, duplicando em 2040 na Europa Ocidental e triplicando na Europa Oriental. Deste modo, a pesquisa para terapias eficazes e diagnósticos precoces é fundamental. Uma característica da AD é a presença de β-amiloide (Aβ), um péptido citotóxico, sob a forma de um agregado extracelular (plaquetas) no cérebro. A STAB VIDA integra um projecto que pretende usar nanopartículas (NPs) para diagnóstico e terapia, isoladamente ou em conjunto (teragnóstico), com especial foco na Aβ cerebral como alvo. A Aβ cerebral e do sangue estão em equilíbrio ao longo da barreira hemato-encefálica (BBB), de um modo que o projecto também considera o Aβ sanguíneo como um potencial alvo. Diferentes NPs (lipossomas, Solid Lipid NPs, NPs polimericas) serão funcionais com:

 

  1. Moléculas que interagem com Aβ;
  2. Moléculas que estimulado a travessia da BBB
  3. Agentes de contraste de PET ou MRI


Modelos artificiais e celulares serão usados para melhorar e afinar a ligação das NP às Aβ, realizar testes de biocompatibilidade, a travessia da BBB e a estabilidade física, minimizando assim o recurso a animais, embora a eficácia das NPs terão se ser em ultima instancia validadas em modelos animais. Serão empregues diferentes vias de administração (ex: oral, nasal) ou diferentes protocolos ( two-step, cocktails de NP, aerossóis com o objectivo de aumentar o fornecimento de NPs no cérebro. Prevê-se que as NP possuam a capacidade de abranger, detectar, desintegrar e remover as Aβ do cérebro. Além disto, irão interagir com as  Aβ do sangue, extraindo assim o excesso de péptido do cérebro, através de um efeito de absorção. As NPs que têm a capacidade de atravessar a BBB podem ser desenhadas poderão ainda ter aplicações potenciais na área  da industria farmacêutica.

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