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Badania Medyczne i Nanotechnologie służące leczeniu Choroby Alzheimera

Projekt NAD (nanocząsteczki w terapii i diagnostyce choroby Alzheimera) dąży do rozwoju nanocząstek w diagnostyce i terapii tej choroby. Badania są finansowane z VII Programu Ramowego Unii Europejskiej i obejmują 19 europejskich ośrodków badawczych. Umowa dotacji nr: CP-IP 212043-2 NAD. Koordynatorem naukowym projektu jest Prof. Masserini z University of Milano-Bicocca.
Najnowsze statystyki wskazują, że 24.3 mln ludzi na świecie jest dotkniętych demencją, a  rocznie przybywa 4.6 mln nowych przypadków (1 nowy przypadek co 7 sekund). W Europie istnieje 5 mln przypadków demencji, wśród nich 3 mln są sklasyfikowane jako choroba Alzheimera. Biorąc pod uwagę ciągły wzrost średniej długości życia, liczby te wzrosną dramatycznie. W 2040 roku liczba chorych podwoi się w Europie Zachodniej i wzrośnie trzykrotnie w Europie Wschodniej. Mimo wielkiego postępu w dziedzinie nauk przyrodniczych, który umożliwił interpretację molekularnych podstaw choroby,  w diagnostyce i terapii nastąpił niewielki postęp.
Celem projektu jest stworzenie nanocząstek (NPs) będących w stanie przekroczyć barierę krew-mózg, aby dotrzeć do mózgu, głównego centrum choroby Alzheimera. Cząsteczeki, które mogą rozpoznać (diagnoza) i zniszczyć (terapia) depozyty amyloidu, charakterystyczne dla choroby Alzheimera, zostaną dołączone do nanocząsteczek i przebadane na modelach zwierzęcych (myszy transgeniczne). Jeśli zostaną osiągnięte odpowiednie rezultaty, wówczas badania nanocząsteczek będą wykonywane na ludziach. Wyniki mogą mieć ogromny wpływ na wczesne rozpoznanie i leczenie choroby Alzheimera.

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