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CHIP-Seq identyfikuje szeroki zakres interakcji białko/kwas nukleinowy. Analizy są ekonomiczne i precyzyjne. Poprzez połączenie Immunoprecypitacji Chromatyny (ChIP) z Sekwencjonowaniem Massively Parallel, CHIP-Seq mogą być wykorzystane do dokładnego badania interakcji pomiędzy białkiem, DNA i RNA, umożliwiając interpretację mechanizmów regulacji wielu procesów biologicznych i stanów chorobowych.

Analizy Small RNASekwencjonowanie Small RNA stanowi ważne zastosowanie NGS, umożliwiając wykrywanie i profilowanie cząsteczek microRNA i innych niekodujących RNA wszystkich organizmów, bez uprzedniej adnotacji genomu. Wykorzystując małe ilości RNA można profilować ekspresję różnicową znanych microRNA, jak również wykryć nowe miejsca docelowe dla mikroRNA i wielu wariantów sekwencji lub "iso-miRs" miRBase rozszerzeń.

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