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El carcinoma de células renales (RCC) es la forma más común de cáncer renal. La tasa de nuevos diagnósticos de CCR está aumentando en un 2% al año, que es un ritmo mucho más rápido que cualquier otro cáncer. En los EE.UU., 275.000 pacientes son examinados para detectar el cáncer de riñón cada año, y 55.000 son diagnosticadas con cáncer renal. La mayoría de los tumores renales se detectan como "hallazgos casuales" de las pruebas de imagen como resonancia magnética o una tomografía computarizada que se realizan por otras razones que el control de los riñones. La mayoría de los tumores (70%) se detectan en etapas tempranas, cuando el tumor es pequeño. Puede ser difícil para los médicos a decir cuál de estas pequeñas masas renales son malignos, y que son benignos. Esta incertidumbre da lugar a cirugías y biopsias innecesarias para diagnosticar definitivamente la presencia de cáncer. Cuando RCC se diagnostica, el tratamiento es la extirpación quirúrgica de todo o parte del riñón afectado. En las primeras etapas donde RCC no se ha diseminado más allá del riñón, la cirugía se realiza con intención curativa. Sin embargo, el 20-40% de los pacientes en etapa temprana que no tienen metástasis detectables en el momento se quita su riñón después desarrollar la enfermedad metastásica. No hay cura para el CCR metastásico, y las pruebas por lo tanto mejor para diagnosticar la presencia de CCR, así como la probabilidad de que un tumor determinado metástasis permitirá mejorar la gestión clínica de la enfermedad.

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Metabolon está desarrollando una prueba para detectar la presencia de CCR mediante la medición de un panel de biomarcadores de metabolitos en sangre u orina. Esta prueba de diagnóstico permite distinguir con precisión las pequeñas masas renales que son RCC, y que son benignos. Esta información permitirá a los médicos a determinar si el paciente requiere biopsia confirmatoria o cirugía, o si se pueden evitar estos procedimientos y se coloca en un programa de vigilancia activa.

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Metabolon también está desarrollando una prueba para medir los metabolitos específicos extraídos de una pequeña cantidad de tejido del tumor extirpado durante la biopsia o la nefrectomía. Al detectar esta firma metabólica que es similar a la más avanzada(los tumores metastásicos T3-T4), la prueba determinará qué tumores en fase inicial (T1-T2), que se supone que son de bajo / riesgo intermedio son en realidad más agresivos. El resultado de esta prueba dará a los médicos información adicional a la estadificación de la patología tradicional de informar a sus decisiones de tratamiento para los pacientes con estadio temprano de CCR.

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Después de RCC ser detectado  y los pacientes son tratados con cirugía (nefrectomía parcial o total), los médicos proporcionan atención de seguimiento a intervalos regulares para verificar si hay signos de recurrencia de la enfermedad (enfermedad metastásica). Lesiones metastásicas muy pequeñas, conocidas como micro-metástasis, son generalmente asintomáticos y que no se puedan detectar en las pruebas de imagen como una tomografía computarizada o una resonancia magnética hasta alcanzar un tamaño más grande. Si estos micro-metástasis se detectan antes, los médicos pueden tratar al paciente antes y más eficazmente. Metabolon está desarrollando una prueba que detecta la presencia de metástasis ocultas y asintomáticas basado en un panel de metabolitos en sangre u orina. Esta prueba está destinada para su uso en el tratamiento de seguimiento, que establecerá, ya sea junto con las pruebas de imagen estándar o como una puerta a las pruebas de imagen. La identificación de la enfermedad metastásica antes ofrece a los médicos información adicional para elegir el tratamiento más adecuado para su paciente.

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