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Estudios recientes sugieren que más de tres millones de personas en los Estados Unidos tienen la Enfermedad de Alzheimer (EA). Este número va a aumentar con el envejecimiento de la población, duplicándose en el año 2040 en Europa Occidental y triplicándose en la Europa Oriental. Por tanto, la búsqueda de terapias eficaces y el diagnóstico precoz es crucial. Una de las características de la EA es la presencia de β-amiloide (Aβ), un péptido citotóxico, en la forma de un agregado extracelular (plaquetas) en el cerebro. STAB VIDA es parte de un proyecto que desea utilizar nanopartículas (NPs) para el diagnóstico y la terapia, individual o conjuntamente (teragnóstico), con especial énfasis en el Aβ cerebral como objetivo. El Aβ del cerebro y el Aβ de la sangre están en equilibrio a lo largo de la barrera hematoencefálica (BBB), de manera que el proyecto también contempla el Aβ sanguíneo como un objetivo potencial. Diferentes NPs (liposomas, Solid Lipid NPs, NPs poliméricos) serán funcionales con:

  1. Moléculas que interactúan con A;
  2. Moléculas estimuladas a través de BBB
  3. Agentes de contraste de PETo MRI

Modelos artificiales y celulares serán utilizados para la mejora y el perfeccionamiento de la unión de NP a Aβ, realizar pruebas de biocompatibilidad, a través de BBB  y la estabilidad física, minimizando así el uso de animales, aunque la efectividad de los NPs serán validados, en última instancia, en modelos animales. Se utilizarán diferentes vías de administración (por ejemplo, oral, nasal) o protocolos diferentes (two-step, cocktails de NP, aerosoles) con el objetivo de incrementar la fuerza de los NPs en el cerebro. Se espera que el NP tenga la capacidad de incluir, detectar, desarticular y eliminar el Aβ en el cerebro. Además, interactuará con el Aβ en sangre, extrayendo así el exceso de péptido del cerebro, a través de un efecto de absorción. Los NPs que tienen la capacidad de atravesar la BBB y pueden ser  diseñados teniendo aplicaciones potenciales en la industria farmacéutica.

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